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The concomitant use of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors could bring about a rise in methadone plasma concentrations, which could bring about perhaps lethal respiratory depression. Additionally, discontinuation of concomitantly applied cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers may end in an increase in m